All statistical tests were performed using SPSS version 21.0, and a value of P < .05 was taken to indicate statistical significance. Table 1. For its subscales scores, the proportions of patients that had ≥1 point reduction were 12% for abdominal, 14% for rectal, and 23% for stool symptoms. The mean drug intake that improved patients’ bowel habits was 39.33 mL (equivalent to 28.9 g) by the measure. Members of _ can log in with their society credentials below, Journal of Evidence-Based Integrative Medicine, This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (. Its stem is erect, branched, and 4–30 in (10–76 cm) high. For more information view the SAGE Journals Article Sharing page. Background: Descurainia sophia seeds have a variety of pharmacological functions and been widely used in traditional folk medicine. However, there is a need for clinical trials with larger sample sizes, longer treatment periods, and a suitable conventional drug for real comparison. AUTHORSHIP AND CITATION: Howard, Janet L. 2003. the site you are agreeing to our use of cookies. Author ContributionsAll authors discussed the concept of the study. In Iranian traditional medicine, Descurainia sophia is used as an antipyretic, antipruritic, purgative, helminthic, aphrodisiac, appetizer, digestive tonic, cardiotonic, astringent, and expectorant. All authors edited and approved the final version of the article. Fifty five (98.2%) children in D. sophia and 50 (94.3%) in PEG group had a history of constipation for more than six months. Before treatment, 82.9% of the patients reported that they had the stool type of 1 and 2 according to the Bristol chart in the previous 6 months and only 14.3% of them reported they had the stool type of 3 and 4. Descurainia sophia Webb ex Prantl; a mini review AJP, Vol. Family: Common Name: Bloom Period: Elevation in meters: Growth Habit: Nativity: Brassicaceae: herb sophia: May-Aug <3000: annual: non-native Either patients or investigator had a moderate satisfaction with the treatment (66 and 69, respectively, in visual analogue scale). Descurainia sophia is a member of the family Brassicaceae. This condition affects different population groups ranging from a low of 0.7% to a high of 81%.1 In the general population, the mean value of chronic constipation prevalence including patient-reported or based on various existing definition criteria is estimated at 12% to 30% of the population,1–4 and for its subtype functional constipation, it is 4.6% to 17%.2,5 Although functional constipation prevalence has not been globally investigated in Iran, recently in Kerman, the biggest city in the Southeast of Iran, it has been estimated at over 9.4%.6 Functional constipation is a heterogeneous condition that, beyond generally decreased frequency of defecation, includes a diversity of symptoms such as bloating, straining, abdominal pain, a feeling of incomplete evacuation, and hard or lumpy stools.7 Despite constipation not being a life-threatening condition, because of its negative effect on patients’ quality of life that subsequently leads to great economic consequences,1 its treatment is considered very important by health providers. Descurainia sophia seed, also known as flixweed, is a member of Brassicaceae family. Tack, J, Van Outryve, M, Beyens, G, Kerstens, R, Vandeplassche, L. View or download all content the institution has subscribed to. It seems that D. sophia L. can modify the digestion process and patients can excrete large amounts of the substance that causes warts.Therefore, it is better to use it more than 40 days. So, in conclusion, Descurainia sophia is safe and effective in the treatment of chronic functional constipation. Stands often become dense and crowded within a few post-disturbance years and which can increase … Two patients did not continue the program because they had to travel to other places. The sample passed all the necessary laboratory items according to the Iran Herbal Pharmacopeia and the World Health Organization. Manuscript content on this site is licensed under Creative Commons Licenses, http://www.creativecommons.org/licenses/by-nc/3.0/, https://us.sagepub.com/en-us/nam/open-access-at-sage, complete spontaneous bowel movements per week, http://www.romecriteria.org/assets/pdf/19_RomeIII_apA_885-898.pdf, Remedies for Children Constipation in Medieval Persia. Its large effect was not limited to stool symptoms, and Descurainia sophia had a large effect on rectal symptoms and a moderate effect on abdominal symptoms (Table 2). U.S. Department of Agriculture, Forest Service, Rocky Mountain Research Station, Fire Sciences Laboratory (Producer). The primary efficacy endpoint was the proportion of patients achieving 3 or more CSBMs/week. I have read and accept the terms and conditions, View permissions information for this article. Create a link to share a read only version of this article with your colleagues and friends. This mucilage may relive constipation.17Descurainia sophia has a compound named allyl disulfidemay that may have a relaxant effect on bowel smooth muscles and facilitate defecation.26 Findings of the study conducted by Nimrouzi et al showed that there was no significant difference between the efficacy of Descurainia sophia and polyethylene glycol in the treatment of functional constipation in children.17 Considering the fact that many studies have confirmed the superiority of polyethylene glycol over other laxatives in the treatment of functional constipation,27–29Descurainia sophia can be used as a safe alternative in the treatment of functional constipation in children. Available: https://www.fs.fed.us/database/feis/plants/forb/dessop/all.html [2020, June 2]. Journal of Evidence-Based Complementary & Alternative Medicine, Epidemiology of constipation in Europe and Oceania: a systematic review, An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking, Epidemiology of constipation in North America: a systematic review, Prevalence of constipation: agreement among several criteria and evaluation of the diagnostic accuracy of qualifying symptoms and self-reported definition in a population-based survey in Spain, Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC), The assessment prevalence of functional constipation and associated factors in adults: a community-based study from Kerman, Southeast, Iran (2011-2012), Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders, Functional Constipation, Complementary and alternative treatments for motility and sensory disorders, Viewpoints of traditional Iranian medicine (TIM) about etiology of pediatric constipation, Abbasian A. viewpoints of Iranian traditional medicine (ITM) about etiology of constipation, Interventions of Iranian traditional medicine for constipation during pregnancy, Phytochemical and pharmacological aspects of, Types of headache and those remedies in traditional Persian medicine, Experimental research on pharmacology and acute toxicology of, Flixweed vs. polyethylene glycol in the treatment of childhood functional constipation: a randomized clinical trial, The functional gastrointestinal disorders and the Rome III process, Psychometric validation of a constipation symptom assessment questionnaire, Diagnostic value of bioelectrical impedance analysis versus body mass index for detection of obesity among students, Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies, A novel sulphur glycoside from the seeds of, Polyethylene glycol versus paraffin for the treatment of childhood functional constipation, Polyethylene glycol 4000 treatment for children with constipation: a randomized comparative multicenter study, Lactulose versus polyethylene glycol for chronic constipation, A placebo-controlled trial of prucalopride for severe chronic constipation, Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation–a 12-week, randomized, double-blind, placebo-controlled study, Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives, A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation, Stool form scale as a useful guide to intestinal transit time, Bristol scale stool form. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? The protocol of this trial was approved by Office of Research Affairs, Deputy of Research and Technology, Shahid Beheshti University of Medical Sciences (Reference Number: 150). In addition, compared with before treatment, patients reported using significantly fewer laxatives per week (Table 3). All eligible patients passed 1 week of washout period of their laxatives. 26 Findings of the study conducted by Nimrouzi et al showed that there was no significant difference between the efficacy of Descurainia sophia and polyethylene glycol in the treatment of functional … Descurainia pinnata: siliques clavate or subclavate in outline, 1-2 mm wide, rounded to obtuse at the apex, and leaf blades usually stipitate glandular (vs. D. sophia, with siliques narrow-linear in outline, mostly 0.5-0.8 mm wide, and leaf blades usually eglandular). Its large effect was not limited to stool symptoms, and Descurainia sophia had a large effect on rectal symptoms and a moderate effect on abdominal symptoms (Table 2). The mean drug intake that improved patients’ bowel habits was 39.33 mL (equivalent to 28.9 g) by the measure. ... which causes adverse side effects, such as gastro-intestinal complications, appetite loss, bone marrow/hematological complications, fatigue, weight loss, and … You can be signed in via any or all of the methods shown below at the same time. Patients provided written informed consent before trial entry. Descurainia sophia, commonly known as flixweed, is an annual (rarely biennial) pioneer herb that colonises disturbed sites and is adapted to growing in dry environments.It is also a crop pest and can facilitate the establishment of other introduced species. Changes in PAC-SYM Items Questionnaire Score. The mean change from baseline in overall scores and their subscales are also illustrated in Table 2. Descurainia sophia var. These disorders include but not are limited to palpitation, dyspepsia, varicose vein, hematologic diseases, varicocele, constipation, and hemorrhoid (Ahmadieh, 2007 ). These herbs help to remove excess of water, salt and toxins from the body. The means of frequency of CSBMs/week before and after treatment are shown in Table 3 (0.51 and 3.49, respectively, P < .001 by Wilcoxon signed-rank test). Before the start of treatment, 62.9% of the patients did not use any laxatives and 25.7% of them used ≥3 laxatives/week (data not provided). Chronic constipation is a common gastrointestinal disorder that effects an estimated 12% to 30% of general population worldwide. Katalog rostlin s vyhledáváním jednotlivých druhů. An effect size of 1.70 showed a significant large effect of Descurainia sophia on stool symptoms of functional constipation. Conventional treatment such as lifestyle changes such as increasing regular physical activity and fiber and fluid intake in the diet or pharmacological intervention such as using laxatives do not satisfy all patients with their treatment. "Roadsides, waste places, disturbed sites, railroad embankments, hillsides, mountain slopes, canyon bottoms, stream banks, fields, lawns, pastures, deserts, sagebrush and pinyon-juniper communities; 0 … We calculated body mass index using the followed equitation: body mass index = weight (kg)/(height (m2))2 and categorized them according to the World Health Organization body mass index principal cutoff points.22 Although current cutoff points of overweightness and obesity may be not suitable in the Persian population,23 as it is not in many Asian populations,24 with regard to minimal data about the suitable cutoff points for Iranian population, we decided to use aforementioned points as a general standard. The overall and subscale score changes are illustrated in Table 2. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? effects of Descurainia sophia on small cell carcinoma of the lung [28,29], colon cancer [30], and glioma [31] have been proved. Similar to a validated original questionnaire we designed a checklist with abdominal, stool, and rectal symptoms subscales. With regard to high safety of Descurainia sophia seed use as a medication up to 2500 mg/kg of body weight,12,25 for this study we asked patients to increase the dose to provide their satisfaction up to 60 mL by the measure (≈50 g). Diuretic herbs effect the Kidneys. Patients were predominantly female and the mean age was 47.8 years. Each item of this list like in the PAC-SYM questionnaire items was scored on a 4-point Likert-type scale with higher scores indicating greater severity. Table 2. Common names include flixweed, herb-Sophia and tansy mustard. AG drafted the first version. In conclusion, in patients with a mean age of 47 years, a history of moderate to severe constipation, 50% of whom were obese and over weighted, Descurainia sophia significantly improved frequency of CSBMs/week and symptoms associated with chronic constipation. The patients also reported a significant high improvement in their stool forms compared with before treatment. With the exception a few patients, reported mild adverse events mainly included headache, nausea, and increased bloating, which were very mild and did not lead to discontinuation from the study; the other patients tolerated the drug easily. For evaluating the constipation-related symptoms, we did not have any Persian-version validated questionnaire of any kind up to the time of study initiation. The means of frequency of CSBMs/week before and after treatment are shown in Table 3 (0.51 and 3.49, respectively, P < .001 by Wilcoxon signed-rank test). Descurainia sophia is used in China for the preparation of health cigarette with a group of * Corresponding author: emadata@yahoo.com ; Phone 0020 165 57 58 70 . Thirty-five patients completed the program with no important adverse effect. So we could not answer the question if benefits of this plant would be maintained with longer treatment. All data were first tested by 1-sample Kolmogorov-Smirnov test. By continuing to browse Members of _ can log in with their society credentials below, Journal of Evidence-Based Integrative Medicine, This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (. Author ContributionsAll authors discussed the concept of the study. We also calculated the proportion of patients that had ≥1 change in their average CSBMs/week. The results reported herein with Descurainia sophia are difficult to compare with other agents because of differences in study design. We calculated body mass index using the followed equitation: body mass index = weight (kg)/(height (m2))2 and categorized them according to the World Health Organization body mass index principal cutoff points.22 Although current cutoff points of overweightness and obesity may be not suitable in the Persian population,23 as it is not in many Asian populations,24 with regard to minimal data about the suitable cutoff points for Iranian population, we decided to use aforementioned points as a general standard. In addition, such side effects may limit treatment programs and hence may affect the prognosis for patients. No statistically significant difference was found between the efficacy of both interventions in the treatment of constipation at the end of the third and eighth weeks of intervention. Importantly, all the aforementioned differences between assessments before and after treatment were statistically significant (P ≤ .002 in Tables 2 and 3). It grows in most parts of the world especially in Asia, Europe, northern Africa, and North America. Contact us if you experience any difficulty logging in. Complementary and alternative medicine has introduced many remedies to ameliorate constipation symptoms.8 Similarly, Iranian traditional medicine introduces some therapeutic methods for treating constipation such as lifestyle changes especially in dietary intake and pharmacological intervention.9–11. The effect size of Descurainia sophia on stool symptoms and forms were prominent. However, their effects on human drug metabolizing enzyme (DME) activities have not been elucidated. Finland: litutilli. In Iranian traditional medicine, Descurainia sophia is used as an antipyretic, antipruritic, purgative, helminthic, aphrodisiac, appetizer, digestive tonic, cardiotonic, astringent, and expectorant. Spanish: ajenjo loco; ajenjo serifio; hieba de la sabiduría; hierba de los cirujanos; Sofia. Characterization of the hot and cold medicinal properties of tradition... Morphological Identification of Lepidii Seu Descurainiae Semen and Adu... Peppas, G, Alexiou, VG, Mourtzoukou, E, Falagas, ME. Sisymbrium persicum Spreng. Conventional treatment such as lifestyle changes such as increasing regular physical activity and fiber and fluid intake in the diet or pharmacological intervention such as using laxatives do not satisfy all patients with their treatment. Nineteen percent of patients had an improvement in the total sore after 4 weeks. The subacute toxicity test was done through oral administration to mice chronic coughs hoarseness. 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